To solve the seismic response problem of a vertical floating roof tank with base isolation, the floating roof is assumed to experience homogeneous rigid circular plate vibration, where the wave height of the vibration is linearly distributed along the radius, starting from the theory of fluid velocity potential; the potential function of the liquid movement and the corresponding theoretical expression of the base shear, overturning the moment, are then established. According to the equivalent principle of the shear and moment, a simplified mechanical model of a base isolation tank with a swinging effect is established, along with a motion equation of a vertical storage tank isolation system that considers the swinging effect based on the energy principle. At the same time, taking a 150,000 m3 large-scale storage tank as an example, a numerical analysis of the dampening effect was conducted using a vibration mode decomposition response spectrum method, and a comparative analysis with a simplified mechanical model with no swinging effect was applied.