Delivery of growth factor-associated genes to mesenchymal stem cells for cartilage and bone tissue regeneration
Jongchan Ahn,Seah Park,Byung-Hyun Cha,Jae Hwan Kim,Hansoo Park,Yoon Ki Joung,Inbo Han,Soo-Hong Lee
Abstract
Genetically-modified mesenchymal stem cells (GM-MSCs) have emerged as promising therapeutic tools for orthopedic degenerative diseases. GM-MSCs have been widely reported that they are able to increase bone and cartilage tissue regeneration not only by secreting transgene products such as growth factors in a long-term manner, also by inducing MSCs into tissue-specific cells. For example, MSCs modified with BMP-2 gene increased secretion of BMP-2 protein resulting in enhancement of bone regeneration, while MSCs with TGF-b gene did cartilage regeneration. In this review, we introduce several growth factors for gene delivery to MSCs and strategies for bone and cartilage tissue regeneration using GM-MSCs. Furthermore, we describe strategies for strengthening GM-MSCs to more intensively induce tissue regeneration by co-delivery system of multiple genes.
Jongchan Ahn, Seah Park, Byung-Hyun Cha, Jae Hwan Kim, Yoon Ki Joung, Soo-Hong Lee: Department of Biomedical Science, CHA University, Bundang-gu, Gyeonggi-do, Republic of Korea
Hansoo Park, Yoon Ki Joung: Department of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea
Inbo Han: Department of Neurosurgery, Bundang Medical Center, CHA University, Bundang-gu, Gyeonggi-do, Republic of Korea
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