Biomaterials and Biomechanics in Bioengineering
Volume 1, Number 2, 2014, pages 73-79
DOI: 10.12989/bme.2014.1.2.073
Polyvinyl butyral DMN-conjugates for the controlled release of singlet oxygen in medical and antimicrobial applications
Damir Posavec, Rainer Muller, Udo Bogner, Gunther Bernhardt and Gunther Knor
Abstract
Covalent attachment of 1, 4-dimethylnaphthalene (DMN) based endoperoxide forming subunits to a polyvinyl butyral (PVB) backbone has been achieved. The functionalized polymer materials prepared and characterized here can serve as biocompatible carrier systems for studying cellular uptake, intermediate storage and delayed release of singlet oxygen, which opens up new doors for optimizing a variety of medical applications of photogenerated DMN-endoperoxides such as antiviral, antibacterial, antiplasmodial and antitumor activity.
Key Words
dimethyl naphthalene; Polyvinyl butyral; endoperoxides; singlet oxygen; drug carriers
Address
Damir Posavec and Gunther Knor: Institute of Inorganic Chemistry, Johannes Kepler University Linz (JKU), Altenbergerstrasse 69, A-4040 Linz, Austria
Rainer Muller and Udo Bogner: Institute of Physical and Theoretical Chemistry, University of Regensburg, 93040 Regensburg, Germany
Gunther Bernhardt: Institute of Pharmacy, University of Regensburg, 93040 Regensburg, Germany