Stability analysis of nano-devices: Exercise-mediated effects on nanodevice stability in drug delivery applications

This study examines the relationship between physical exercise and the stability of nanodevices intended for targeted drug-delivery systems, emphasizing applications in sports science and medicine. The hemodynamic changes resulting from physical activity, including fluctuations in blood flow velocity and pressure, are essential factors affecting the performance and stability of nanodevices in the bloodstream. A modified continuum modeling approach that integrates high-order beam theory and nonlocal strain gradient theory is employed to simulate the dynamic behavior of nanodevices with nonuniform tubular geometries. The proposed design of the nanodevice includes a central nanomotor and two truncated conical nanotubes, functioning as nanoblades for the accurate transport and release of therapeutic agents. Numerical simulations investigate the nanodevice's rotational and vibrational stability under physiologically relevant conditions, such as changes in physical training intensity and blood flow patterns. This study thoroughly explores how essential aspects such as device design, material properties, and exercise-induced hemodynamic forces affect nanodevice performance. The results are corroborated by existing published data, indicating the potential for improved drug-delivery efficiency in active individuals. This research integrates mechanical engineering principles with sports science to establish a framework for developing advanced nanodevices suited to dynamic physiological environments, which has important implications for sports medicine, rehabilitation, and personalized healthcare.