Advances in Nano Research

Volume 18, Number 5, 2025, pages 419-432

DOI: 10.12989/.2025.18.5.419

Exercise-induced changes in protein tissue stability in athletes via biomechanical analysis using size-dependent mechanical models

Chaofan Chen , Xiangzi Xiao , Liang Chen , Mostafa Habibi , Ameni Brahmia , Xiaodao Chen

Abstract

Protein stability has been recognized as a critical factor influencing athletic performance, recovery, and injury prevention during physical exercise. Despite widespread recognition, the mechanisms by which exercise influences the stability of protein tissues and fibers remain incompletely understood. This study uses complex mechanical theories and numerical simulations to investigate how exercise impacts protein stability. Size-dependent mechanical models are employed to analyze the small-scale behavior of protein tissues under exercise-induced stress, including strain rate, tissue microstructure, and exercise intensity. Numerical approaches are used to simulate proteins' dynamic behavior, offering insights into their deformation and failure processes under a wide range of situations. The results demonstrate that exercise substantially influences protein stability, with significant variations depending on the kind and intensity of the physical activity. These findings provide novel insights into the importance of protein stability in athletic performance and recovery, highlighting practical implications for training optimization, injury prevention, and broader applications in sports science. This study emphasizes the importance of protein stability for exercise and athletic performance by integrating biomechanics and sports science.

Key Words

athletic performance; biomechanical analysis; exercise-induced changes; numerical simulations; protein stability; size-dependent models

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