The microcantilever (MCL) sensor is one of the most promising platforms for next-generation label-free biosensing applications. It outperforms conventional label-free detection methods in terms of portability and parallelization. In this paper, an overview of recent advances in our understanding of the coupling between
biomolecular interactions and MCL responses is given. A dual compact optical MCL sensing platform was built
to enable biosensing experiments both in gas-phase environments and in solutions. The thermal bimorph effect
was found to be an effective nanomanipulator for the MCL platform calibration. The study of the alkanethiol
self-assembly monolayer (SAM) chain length effect revealed that 1-octanethiol (C8H17SH) induced a larger deflection than that from 1-dodecanethiol (C12H25SH) in solutions. Using the clinically relevant biomarker Creactive
protein (CRP), we revealed that the analytical sensitivity of the MCL reached a diagnostic level of 1~500
Chuin-Shan Chen, Tzu-Hsuan Chang, Chia-Ching Chou and
Shu-Wei Chang: Department of Civil Engineering, National Taiwan University, Taipei 10617, Taiwan
Shu Kuan and Long-Sun Huang: Institute of Applied Mechanics, National Taiwan University, Taipei 10617, Taiwan
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