Exploring and calibrating local curvature effect of cortical bone for quantitative ultrasound (QUS)
Jiangang Chen,Zhongqing Su,Li Cheng,De-an Ta
Abstract
Apart from thinning of cortical layers, the local bone curvature, varying along bone periphery, modulates ultrasound waves as well, which is however often underestimated or overlooked in clinical quantitative ultrasound (QUS). A dedicated three-dimensional finite element modelling technique for cortical bones was established, for quantitatively exploring and calibrating the effect of local curvature of cortical bone on ultrasound. Using a correlation-based mode extraction technique, high-velocity group (HVG) and low-velocity group (LVG) wave modes in a human radius were examined. Experimental verification using acrylic cylinders and in vitro testing using a porcine femur were accomplished. Results coherently unravelled the cortical curvature exerts evident influence on bone-guided ultrasound when RoC/n
Key Words
local bone curvature; cortical bone; bone modelling; quantitative ultrasound (QUS); highvelocity group wave; low-velocity group wave; in vitro testing
Address
Jiangang Chen, Zhongqing Su, Li Cheng — The Department of Mechanical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong
Jiangang Chen — The Ultrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA
De-an Ta — The Department of Electronic Engineering, Fudan University, Shanghai, P.R. China
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